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Stem Cell Related Patent Number US6258354
| Title: | Method for homing hematopoietic stem cells to bone marrow stromal cells | | Inventors: | Greenberger, Joel S.; Lincoln, MA, USA | | Summary: | Described herein are methods of homing hematopoietic stem cells to transplanted bone marrow stromal cells and inducing proliferation of the stem cells. The invention relates to a process for homing hematopoietic stem cells to bone marrow stromal cells in a host via the administration to the host of genetically-engineered hematopoietic stem cells which are capable of expressing a first member of a ligand-receptor binding pair, under conditions in which the binding of the first member of the ligand-receptor binding pair to the second member of the ligand-receptor binding pair, as present on stromal cells, constitutes the homing of the stem cells to the stromal cells. Therapeutic applications in bone marrow transplantation are included. | | Abstract: | This invention pertains to a method for homing hematopoietic stem cells to bone marrow stromal cells in a host. The method comprises, administering to the host genetically-engineered hematopoietic stem cells capable of expressing a first member of a ligand-receptor binding pair. The stem cells are administered to the host under conditions whereby binding of the first member of the ligand-receptor binding pair to the second member of the ligand-receptor binding pair, present on stromal cells, occurs thereby homing the stem cells to the stromal cells. This method is useful for transplanting bone marrow in a host or in treating a host afflicted with a disease associated with a disorder of the bone marrow. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6258354 | | Application Number: | US1992000888203 | | Date Filed: | 26/05/1992 | | Date Published: | 10/07/2001 | | Assignee: | None |
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