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Stem Cell Related Patent Number US6261549

Title:Human mesenchymal stem cells from peripheral blood
Inventors:Fernandez, Mireya; Santiago, Chile
Minguell, Jose J.; Santiago, Chile
Summary:This invention introduces methods for obtaining human mesenchymal stem cells from peripheral blood via the administration to a patient of at least one growth factor which increases the amount of mesenchymal cells that are recoverable from peripheral blood. Described herein are growth factors which preferably include G-CSF, GM-CSF and combinations thereof, along with the methods of use of such factors in the recovery of an isolated, culture-expanded population of human mesenchymal stem cells from the mesenchymal stem cell-enriched peripheral blood of an individual. Further disclosed are methods of preserving ex vivo such an isolated, culture-expanded population of human mesenchymal stem cells from peripheral blood, as well as methods for treating an individual with an isolated, culture-expanded population of human mesenchymal stem cells in the treatment of various diseases.
Abstract:Disclosed is a method for recovering peripheral blood containing a population of cells enhanced in human mesenchymal stem cells from an individual by (i) administering to said individual at least one growth factor and, thereafter, (ii) recovering peripheral blood from said individual. The growth factors preferably include G-CSF, GM-CSF and combinations thereof. Any of the known human growth factors or combinations thereof are suitable. Also disclosed is a method for recovering an isolated, culture-expanded population of human mesenchymal stem cells from the mesenchymal stem cell-enriched peripheral blood of an individual. Also disclosed is a method for preserving ex vivo an isolated, culture-expanded population of human mesenchymal stem cells from the mesenchymal stem cell-enriched peripheral blood. Also disclosed is a method for treating an individual with an isolated, culture-expanded population of human mesenchymal stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6261549
Application Number:US1998000108838
Date Filed:01/07/1998
Date Published:17/07/2001
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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