Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6261841

Title:Compositions, kits, and methods for modulating survival and differentiation of multi-potential hematopoietic progenitor cells
Inventors:Cohen, Isaac; Wilmette, IL, USA
Lefebvre, Phil; Chicago, IL, USA
Lin, Jiandie; Evanston, IL, USA
Linzer, Daniel; Evanston, IL, USA
Summary:Described herein are methods and materials for maintaining mammalian hematopoietic progenitor cells in vitro, and modulating the survival and differentiation of mammalian hematopoietic progenitor cells via a process of maintaining the cells in a nutritive medium containing a placental glycoprotein hormone of the murine prolactin family, namely, either murine prolactin-like protein E or F. The invention relates to methods, compositions, and kits which can be used for the in vitro or ex vivo expansion of hematopoietic precursor cells or for the treatment of a disorder associated with aberrant hematopoiesis, such as pre-eclampsia and thrombocytopenia.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US6261841
Application Number:US2000000602848
Date Filed:23/06/2000
Date Published:17/07/2001
Assignee:The Board of Trustees of Northwestern University, Evanston, IL, USA


 
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