Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6271028

Title:Hematopoietic cell method for treatment of HIV infection
Inventors:O'Donnell, Jr., Francis E.; St. Louis, MO, USA
Summary:Described herein are methods of preparing host cells, namely, autologous lymphocytes, which are devoid of infrastructure and required for viral replication, by treating the cells in vitro, with a multi-drug array of antivirals and/or ionizing radiation in conjunction with chemotherapy. This invention addresses the risk of drug resistance in HIV infection and proposes a reduction of such resistance by suppression of the viral load using novel hematopoietic cells. Methods are provided by which modified CD4 lymphocyte host cells are used to capture virions in a sterile micro-environment, such that the host's CD4 T-cell lymphocytes are replaced with lymphocytes derived from autologous or homologous stem cells which do not express the CKR-5 receptor, thereby further inhibiting viral load.
Abstract:The risk of drug resistance in HIV infection is reduced by profoundly suppressing the viral load using novel hematopoietic cells. Modified CD4 lymphocyte host cells are used to capture virions in a sterile micro-environment. The host's CD4 T-cell lymphocytes are replaced with lumphocytes derived from autologous or homologous stem cells which do not express the CKR-5 receptor, further inhibiting viral load.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6271028
Application Number:US1997000910084
Date Filed:12/08/1997
Date Published:07/08/2001
Assignee:None


 
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