Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6280957

Title:Costimulatory blockade and mixed chimerism in allo-transplantation
Inventors:Sayegh, Mohamed; Westwood, MA, USA
Sykes, Megan; Charlestown, MA, USA
Summary:Described herein are methods and materials for promoting the acceptance of an allograft in a recipient. The invention relates to the use of a blockade of costimulation and hematopoietic stem cells in an allograft transplantation for a recipient mammal receiving a graft from a donor mammal of the same species. Specific properties of the inhibitor of the CD40 ligand-CD40 costimulatory interaction are provided.
Abstract:Use of the blockade of costimulation and hematopoietic stem cells in allograft transplantation.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6280957
Application Number:US1999000245614
Date Filed:04/02/1999
Date Published:28/08/2001
Assignee:The General Hospital Corporation, Charlestown, MA, USA


 
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