Methods comprising apoptosis inhibitors for the generation of transgenic pigs |
 |
|
|
||||||||||||||||||||||||||||||||||||||||||
| Title: | Functional characterization of the C-C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2 |
| Inventors: | Fife, Kenneth H.; Zionsville, IN, USA Krathwohl, Michell D.; Indianapolis, IN, USA Hromas, Robert; Indianapolis, IN, USA Brown, Darron R.; Zionsville, IN, USA Broxmeyer, Hal E.; Indianapolis, IN, USA |
| Summary: | This invention describes novel isolated chemokine-like polypeptides obtained from the molluscum contagiosum virus (MCV). Described herein are cloned and expressed chemokine-like genes from the MCV type 1 and also from the closely related MCV type 2, and methods of determining a potential role for these proteins in the viral life cycle. Claims of the invention include the first viral chemokines that have been shown to antagonize the chemotactic activity of human chemokines, and the first viral chemokines that have been shown to have inhibitory activity on human hematopoietic progenitor cells. Further provided are specific amino acid sequences, as are therapeutic applications in the development of products for the treatment of inflammation, allergy, asthma or autoimmune disorders. |
| Abstract: | The inventors have cloned and expressed the chemokine-like genes from MCV type 1 and the closely related MCV type 2 in order to determine a potential role for these proteins in the viral life cycle. These are the first viral chemokines that have been shown to antagonize the chemotactic activity of human chemokines and the first viral chemokines that have been shown to have inhibitory activity on human hematopoietic progenitor cells. Methods and compositions for exploiting these proteins are disclosed herein. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6281200 |
| Application Number: | US1998000133521 |
| Date Filed: | 13/08/1998 |
| Date Published: | 28/08/2001 |
| Assignee: | Advanced Research and Technology Institute, Bloomington, IN, USA |