Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6284944

Title:Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring
Inventors:Scott, Richard W.; West Chester, PA, USA
Reaume, Andrew G.; West Chester, PA, USA
Dorfman, Karen; West Chester, PA, USA
Summary:This invention discloses a gene-targeted non-human mammal and generational offspring with a gene encoding a mutant protein product of a mutated presenilin 1 gene (PS-1). More specifically, described herein is a gene-targeted mouse heterozygous or homozygous for the human presenilin-1 mutation P264L, with respect to the gene sequence encoding the mutant protein product of PS-1 which has been mutated to contain the human P264L mutation. Methods for screening chemical compounds using such mammals are also disclosed. From the active PS-1 protein comprising the human P264L mutation, the PS-1 protein is expressed, wherein the A?42 protein level is elevated relative to the A?42 protein level in a wild-type mouse. Also provided are uses of this model to elucidate the role of the presenilin-1 mutation in the pathology and symptomatology of Alzheimer's disease.
Abstract:This invention discloses a gene-targeted non-human mammal and generational offspring with respect to the gene encoding a mutant protein product of a mutated presenilin 1 gene (PS-1); more specifically, a gene-targeted mouse with respect to the gene sequence encoding the mutant protein product of PS-1 which has been mutated to contain the human P264L mutation. Methods for screening chemical compounds using such mammals are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6284944
Application Number:US1998000041185
Date Filed:10/03/1998
Date Published:04/09/2001
Assignee:Cephalon, Inc,, West Chester, PA, USA


 
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