|
|
|
Stem Cell Related Patent Number US6284944
| Title: | Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring | | Inventors: | Scott, Richard W.; West Chester, PA, USA
Reaume, Andrew G.; West Chester, PA, USA
Dorfman, Karen; West Chester, PA, USA | | Summary: | This invention discloses a gene-targeted non-human mammal and generational offspring with a gene encoding a mutant protein product of a mutated presenilin 1 gene (PS-1). More specifically, described herein is a gene-targeted mouse heterozygous or homozygous for the human presenilin-1 mutation P264L, with respect to the gene sequence encoding the mutant protein product of PS-1 which has been mutated to contain the human P264L mutation. Methods for screening chemical compounds using such mammals are also disclosed. From the active PS-1 protein comprising the human P264L mutation, the PS-1 protein is expressed, wherein the A?42 protein level is elevated relative to the A?42 protein level in a wild-type mouse. Also provided are uses of this model to elucidate the role of the presenilin-1 mutation in the pathology and symptomatology of Alzheimer's disease. | | Abstract: | This invention discloses a gene-targeted non-human mammal and generational offspring with respect to the gene encoding a mutant protein product of a mutated presenilin 1 gene (PS-1); more specifically, a gene-targeted mouse with respect to the gene sequence encoding the mutant protein product of PS-1 which has been mutated to contain the human P264L mutation. Methods for screening chemical compounds using such mammals are also disclosed. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6284944 | | Application Number: | US1998000041185 | | Date Filed: | 10/03/1998 | | Date Published: | 04/09/2001 | | Assignee: | Cephalon, Inc,, West Chester, PA, USA |
|
|
