Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6287537

Title:Radioimmunotherapy of lymphoma using anti-CD20 antibodies
Inventors:Kaminski, Mark S.; Ann Arbor, MI, USA
Butchko, Gregory M.; Lake Forest, IL, USA
Glenn, Stephan D.; Sunnyvale, CA, USA
Wahl, Richard L.; Ann Arbor, MI, USA
Summary:This invention introduces a radioimmunotherapeutic process for the treatment of B-cell lymphoma. The invention relates to methods of immunotherapy via the administration of a radiolabeled antibody and an unlabeled antibody that binds to the antigen on the surface of the cells of B-cell lymphoma. Further provided are methods by which a patient is provided with both the unlabeled antibodies and the antibodies labeled with a radioisotope. Claims of the invention include tumor responses which can be obtained in a radiometric dosage range that does not require hematopoietic stem cell replacement as an adjunct therapy.
Abstract:Methods for the treatment of lymphoma by adminstration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6287537
Application Number:US1998000087392
Date Filed:29/05/1998
Date Published:11/09/2001
Assignee:The Regents of the University of Michigan, Ann Arbor, MI, USA Coulter Pharmaceutical, Inc., South San Francisco, CA, USA


 
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