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Stem Cell Related Patent Number US6291210
| Title: | Differentiation inhibitor | | Inventors: | Sakano, Seiji; Shizuoka, Japan
Itoh, Akira; Shizuoka, Japan | | Summary: | This invention introduces human serrate-2 gene expression products, methods and uses thereof. Described herein is a novel human serrate-2 polypeptide consisting of a polypeptide capable of regulating the differentiation of undifferentiated cells from stem cells. Specific amino acid sequences are provided, as are genetic properties as well as the antibodies specifically recognizing the polypeptide, and methods of their production. Therapeutic applications include the regulation of stem cell differentiation in the treatment of a variety of neoplasms, such as leukemia. | | Abstract: | A novel human serrate-2 polypeptide consisting of a polypeptide containing the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing and having the effect of regulating the differentiation of undifferentiated cells involving stem cells; its gene; a process for producing the same; and an antibody specifically recognizing the polypeptide. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6291210 | | Application Number: | US1999000214278 | | Date Filed: | 26/01/1999 | | Date Published: | 18/09/2001 | | Assignee: | Asahi Kasei Kabushiki Kaisha, Osaka, Japan |
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