Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6306651

Title:Specific tolerance in transplantation
Inventors:Sachs, David H.; Newton, MA, USA
Summary:This invention describes a nucleic acid encoding a mammalian MHC antigen, methods and uses thereof. Described herein is a process of inducing tolerance in a recipient human mammal to a tissue obtained from another mammal, such as a swine or miniature swine, such that the tissue expresses an MHC antigen. Further disclosed are methods of inserting the DNA encoding an MHC antigen into a bone marrow hematopoietic stem cell from the recipient mammal, and allowing the MHC antigen encoding the DNA to be expressed in the recipient. Therapeutic applications in preventing the rejection of transplanted tissue are provided.
Abstract:In general, the invention features, a method of inducing tolerance in a recipient mammal, e.g., a human, of a first species to a tissue obtained from a mammal, e.g., a swine, e.g., a miniature swine, of a second species, which tissue expresses an MHC antigen, including inserting DNA encoding an MHC antigen of the second species into a bone marrow hematopoietic stem cell from the recipient mammal, and allowing the MHC antigen encoding DNA to be expressed in the recipient.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6306651
Application Number:US1997000910287
Date Filed:13/08/1997
Date Published:23/10/2001
Assignee:The General Hospital Corporation, Boston, MA, USA


 
Copyright © 2007 The Institute for Cellular Medicine  8/13/2020