Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6313373

Title:Tissue specific promoters and transgenic mouse for the screening of pharmaceuticals
Inventors:Eckert, Richard L.; Cleveland Hts., OH, USA
Crish, James F.; North Olmsted, OH, USA
Summary:This invention describes human involucrin (hINV) sequences having tissue-specific and cell type-specific promoter activity. Further disclosed are sequences which direct expression to suprabasal cells of stratifying epithelia, as well as methods for the production of transgenic animals which contain a hINV promoter sequence directing the expression of human papillomavirus 16 oncogenes, or other oncogenes. Such animals display cervical and epidermal hyperplasias as well as cancer of the trachea, esophagus, colon, epidermis, anus/rectum, lymph nodes, spleen and lung. Methods are also described for the use of this model in the screening of potential anti-neoplastic compounds, carcinogens, and co-carcinogens for a number of cancers.
Abstract:The present invention provides human involucrin (hINV) sequences having tissue specific and cell type specific promoter activity. The sequences provided herein direct expression to suprabasal cells of stratifying epithelia. The invention further provides methods for the production of transgenic animals which contain a hINV promoter sequence which directs the expression of human papillomavirus 16 oncogenes (or other oncogenes). These animals display cervical and epidermal hyperplasias as well as cancer of the trachea, esophagus, colon, epidermis, anus/rectum, lymph nodes, spleen and lung. The animals of the invention provide a useful model for screening potential anti-neoplastic compounds, carcinogens, and co-carcinogens for a number of cancers.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6313373
Application Number:US1999000430201
Date Filed:29/10/1999
Date Published:06/11/2001
Assignee:Case Western Reserve University, Cleveland, OH, USA


 
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