Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6328960

Title:Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
Inventors:McIntosh, Kevin R.; Ellicott City, MD, USA
Mosca, Joseph D.; Ellicott City, MD, USA
Klyushnenkova, Elena N.; Baltimore, MD, USA
Summary:Described herein are novel uses of mesenchymal stem cells for preventing, reducing or treating transplant rejection or graft-versus-host disease. The invention relates to a process of reducing an immune response of effector cells against an alloantigen in a recipient by treating the recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. Further disclosed are methods by which the mesenchymal stem cells may be administered before, during or after the transplant.
Abstract:Disclosed is a method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the transplant. The mesenchymal stem cells can be administered before, at the same time as, or after the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with mesenchymal stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6328960
Application Number:US1999000267536
Date Filed:12/03/1999
Date Published:11/12/2001
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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