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Stem Cell Related Patent Number US6335175
| Title: | Anti-human pre-B cell receptor antibody | | Inventors: | Tsuganezawa, Keiko; Kanagawa, Japan
Karasuyama, Hajime; Koganei-shi, Tokyo 184-0015, Japan | | Summary: | This invention introduces novel human pre-B cell receptor monoclonal antibodies produced by hybridoma HSL2, and antibodies reacting with V pre-B molecules. Described herein is an antibody which recognizes a human pre-B cell receptor and does not recognize a human pro-B cell. Further disclosed are methods of diagnosing at which stage of B cell differentiation the acute childhood form of lymphoblastic leukemia develops. Methods of use are provided for such antibodies. Therapeutic applications emphasize the diagnosis of acute lymphatic leukemia in infants. | | Abstract: | The present invention provides an antibody which recognizes a human pre-B cell receptor and does not recognize a human pro-B cell. The invention also provides an antibody which reacts with a VpreB molecule, one of the constituents of an SL chain of a human pre-B cell receptor expressed on the membrane surface of a human pre-B cell, or a VpreB molecule expressed within a human pro-B cell, but does not react with a .lambda.5 molecule of the surrogate light chain, and whose reactivity is such that a human pre-B cell or a human pro-B cell reacted with the antibody can be detected microscopically. The invention further provides a method for diagnosing which differentiation stage of B cells acute lymphoblastic leukemia in childhood stems from, by using an antibody which recognizes a human pre-B cell receptor, and does not recognize a human pro-B cell, an antibody which recognizes a VpreB molecule of a surrogate light chain constituting a human pre-B cell receptor, an antibody which recognizes a .lambda.5 molecule of the surrogate light chain constituting a human pre-B cell receptor, and an antibody which recognizes a B cell. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6335175 | | Application Number: | US2000000494252 | | Date Filed: | 31/01/2000 | | Date Published: | 01/01/2002 | | Assignee: | Sumitomo Electric Industries, Ltd., Osaka, Japan
Karasuyama; Hajime, Tokyo, Japan |
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