Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6335175

Title:Anti-human pre-B cell receptor antibody
Inventors:Tsuganezawa, Keiko; Kanagawa, Japan
Karasuyama, Hajime; Koganei-shi, Tokyo 184-0015, Japan
Summary:This invention introduces novel human pre-B cell receptor monoclonal antibodies produced by hybridoma HSL2, and antibodies reacting with V pre-B molecules. Described herein is an antibody which recognizes a human pre-B cell receptor and does not recognize a human pro-B cell. Further disclosed are methods of diagnosing at which stage of B cell differentiation the acute childhood form of lymphoblastic leukemia develops. Methods of use are provided for such antibodies. Therapeutic applications emphasize the diagnosis of acute lymphatic leukemia in infants.
Abstract:The present invention provides an antibody which recognizes a human pre-B cell receptor and does not recognize a human pro-B cell. The invention also provides an antibody which reacts with a VpreB molecule, one of the constituents of an SL chain of a human pre-B cell receptor expressed on the membrane surface of a human pre-B cell, or a VpreB molecule expressed within a human pro-B cell, but does not react with a .lambda.5 molecule of the surrogate light chain, and whose reactivity is such that a human pre-B cell or a human pro-B cell reacted with the antibody can be detected microscopically. The invention further provides a method for diagnosing which differentiation stage of B cells acute lymphoblastic leukemia in childhood stems from, by using an antibody which recognizes a human pre-B cell receptor, and does not recognize a human pro-B cell, an antibody which recognizes a VpreB molecule of a surrogate light chain constituting a human pre-B cell receptor, an antibody which recognizes a .lambda.5 molecule of the surrogate light chain constituting a human pre-B cell receptor, and an antibody which recognizes a B cell.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6335175
Application Number:US2000000494252
Date Filed:31/01/2000
Date Published:01/01/2002
Assignee:Sumitomo Electric Industries, Ltd., Osaka, Japan Karasuyama; Hajime, Tokyo, Japan


 
Copyright © 2007 The Institute for Cellular Medicine  6/18/2021