Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6337184

Title:Molecular marker for muscle stem cells
Inventors:Miller, Jeffrey B.; Cambridge, MA, USA
Summary:This invention introduces methods of identifying a muscle stem cell via the detection of Bcl-2 promoter activity within a sample containing myogenic cells. Central to the invention is Bcl-2 expression as a molecular marker for muscle stem cells, for which methods are provided herein for determining whether a test compound modulates muscle stem cell differentiation or proliferation. Further disclosed are methods for expressing an exogenous coding sequence in a muscle stem cell.
Abstract:In accordance with the invention, Bcl-2 expression is a molecular marker for muscle stem cells. Thus, the invention provides methods for identifying and isolating muscle stem cells. In addition, the invention provides methods for determining whether a test compound modulates muscle stem cell differentiation and/or proliferation. Finally, the invention provides methods for expressing an exogenous coding sequence in a muscle stem cell.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6337184
Application Number:US1998000053031
Date Filed:01/04/1998
Date Published:08/01/2002
Assignee:None


 
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