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Stem Cell Related Patent Number US6342220
| Title: | Agonist antibodies | | Inventors: | Adams, Camellia W.; Mountain View, CA, USA
Carter, Paul J.; San Francisco, CA, USA
Fendly, Brian M.; Half Moon Bay, CA, USA
Gurney, Austin L.; Belmont, CA, USA | | Summary: | This invention introduces novel thrombopoietin receptor agonist antibodies, methods and uses thereof. Central to the invention are various forms of c-mpl agonist antibodies which have been shown to influence the replication, differentiation and maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Amino acid sequences are disclosed, as are uses of these compounds in the treatment of thrombocytopenia. Therapeutic applications include the treatment of immunological or hematological disorders | | Abstract: | Various forms of c-mpl agonist antibodies are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6342220 | | Application Number: | US1997000918148 | | Date Filed: | 25/08/1997 | | Date Published: | 29/01/2002 | | Assignee: | Genentech, Inc., South San Francisco, CA, USA |
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