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Stem Cell Related Patent Number US6348050
| Title: | Infusion systems for creating microenvironments in a living body | | Inventors: | Hartlaub, Jerome T.; New Brighton, MN, USA | | Summary: | Described herein are methods of maintaining a microenvironment in a living body via implantable infusion systems which deliver therapy to target sites. The invention relates to implantable infusion systems for the prolonged infusion of a carefully designed medicament composition which delivers exogenous substances to maintain a microenvironment in the living body. Further disclosed are components of the medicament compositions which include stem cells including homographs and allographs, adhesive peptides, substances which inhibit fibroblast growth, genetically modified cells which produce the exogenous substances, and nerve growth factor (NGF). Also provided are the means with which the replication of cells in a reservoir may be used to keep cells alive in a dormant state until infusion. | | Abstract: | The invention provides implantable infusion systems, including apparatus and methods, for prolonged infusion of a carefully designed medicament composition to create and maintain a comprehensive microenvironment at a target area in a living body. The composition may include living cells to treat a particular disease and which deliver exogenous substances to maintain a microenvironment in the living body. The invention contemplates medicament compositions that include stem cells (neuro or otherwise), including homographs and allographs, adhesive peptides, substances which inhibit fiberblast growth, genetically modified cells which produce useful exogenous substances, nerve growth factor (NGF), previously harvested cells from a living body. In another aspect, the invention contemplates the replication of cells in a reservoir, for example, to keep cells alive in a dormant state until infusion. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6348050 | | Application Number: | US1999000303033 | | Date Filed: | 30/04/1999 | | Date Published: | 19/02/2002 | | Assignee: | Medtronic, Inc., Minneapolis, MN, USA |
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