Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6355239

Title:Uses for non-autologous mesenchymal stem cells
Inventors:Bruder, Scott P.; Waltham, MA, USA
Summary:Described herein are methods for promoting connective tissue growth in a human subject via the administration of allogeneic mesenchymal stem cells. The invention relates to methods by which non-autologous mesenchymal stem cells are prepared and administered for the regenerative treatment of connective tissue and bone marrow enhancement during engraftment. Further disclosed are methods of genetically engineering allogeneic human mesenchymal stem cells that carry within them specific genes of interest, such as for the expression of physiologically or pharmacologically active proteins in gene therapy. Applications in the correction of genetic disorders and in the regeneration of tissue are included.
Abstract:Methods and devices using non-autologous mesenchymal stem cells comprising treating a recipient in need thereof with an effective amount of non-autologous mesenchymal stem cells, including methods and preparations for treating and regenerating connective tissue and enhancing bone marrow engraftment in an individual; and for using genetically engineered allogeneic human mesenchymal stem cells that carry within them genes of interest particularly for the expression of physiologically or pharmacologically active proteins in gene therapy for correction of genetic disorders or rebuilding proteins important in tissue repair.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6355239
Application Number:US1999000314855
Date Filed:12/03/1999
Date Published:12/03/2002
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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