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Stem Cell Related Patent Number US6355476
| Title: | Nucleic acid encoding MIP-1fpa Lymphokine | | Inventors: | Kwon, Byoung Se; Carmel, IN, USA | | Summary: | Described herein is a novel isolated and purified cDNA designated L25G25B encoding the mouse lymphokine macrophage inflammatory protein 1 alpha, methods and uses thereof. The invention relates to the full-length isolated and sequenced cDNAs, L2G25B and 4-1BB, such that the cDNA L2G25B encodes for the lymphokine macrophage inflammatory protein-1?a or MIP-1?a, and the cDNA clone 4-1BB is described as an inducible receptor-like sequence found in both cytolytic and helper T-cells. Properties of MIP-1?a and MIP-? include their ability to modulate early myeloid progenitor cell proliferation, while recombinant proteins have been produced for the cytokine, L2G25BP. Therapeutic applications include the myelosuppressive activity of rmuMIP-1?a in vivo. | | Abstract: | | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6355476 | | Application Number: | US1992000922996 | | Date Filed: | 30/07/1992 | | Date Published: | 12/03/2002 | | Assignee: | Advanced Research and Technology Institute, Indianapolis, IN, USA |
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