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Stem Cell Related Patent Number US6361996
| Title: | Neuroepithelial stem cells and glial-restricted intermediate precursors | | Inventors: | Rao, Mahendra S.; Salt Lake City, UT, USA
Mayer-Proschel, Margot; Sandy, UT, USA | | Summary: | Described herein are mammalian neuroepithelial stem cells and glial restricted precursor cells which are capable of self-renewal and differentiation into central nervous system cells. The invention relates to multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells resulting from a homogeneous population of neuroepithelial stem cells derived from the neural tube of a rat embryo. The neuroepithelial stem cells are described as being capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. By comparison, the oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells and are capable of self-renewal and differentiation into oligodendrocytes and astrocytes, but not neurons. Further disclosed are methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells. | | Abstract: | Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells are also disclosed. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6361996 | | Application Number: | US1997000852744 | | Date Filed: | 07/05/1997 | | Date Published: | 26/03/2002 | | Assignee: | University of Utah Research Foundation, Salt Lake City, UT, USA |
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