Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6361996

Title:Neuroepithelial stem cells and glial-restricted intermediate precursors
Inventors:Rao, Mahendra S.; Salt Lake City, UT, USA
Mayer-Proschel, Margot; Sandy, UT, USA
Summary:Described herein are mammalian neuroepithelial stem cells and glial restricted precursor cells which are capable of self-renewal and differentiation into central nervous system cells. The invention relates to multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells resulting from a homogeneous population of neuroepithelial stem cells derived from the neural tube of a rat embryo. The neuroepithelial stem cells are described as being capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. By comparison, the oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells and are capable of self-renewal and differentiation into oligodendrocytes and astrocytes, but not neurons. Further disclosed are methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells.
Abstract:Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6361996
Application Number:US1997000852744
Date Filed:07/05/1997
Date Published:26/03/2002
Assignee:University of Utah Research Foundation, Salt Lake City, UT, USA


 
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