Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6365404

Title:Hematopoietic cell method for treatment of HIV infection
Inventors:O'Donnell, Jr., Francis E.; St. Louis, MO, USA
Summary:Described herein are methods of reducing human immunodeficiency virus replication in vivo by the administration to a patient of modified T cells which have been rendered incapable of hosting viral replication. This invention addresses the problem of drug resistance in HIV infection, and methods are introduced for reducing such drug resistance by suppression of the viral load using novel hematopoietic cells. Namely, modified CD4 lymphocyte host cells are used to “capture” virons in a sterile micro-environment, after which the host's CD4 T-cell lymphocytes are then replaced with lymphocytes derived from autologous or homologous stem cells which do not express the CKR-5 receptor and which further inhibit the viral load.
Abstract:The risk of drug resistance in HIV infection is reduced by profoundly suppressing the viral load using novel hematopoietic cells. Modified CD4 lymphocyte host cells are used to capture virons in a sterile micro-environment. The host's CD4 T-cell lymphocytes are replaced with lymphocytes derived from autologous or homologous stem cells which do not express the CKR-5 receptor, further inhibiting viral load.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6365404
Application Number:US2000000545365
Date Filed:07/04/2000
Date Published:02/04/2002
Assignee:None


 
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