Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6365796

Title:Transgenic UCP2 knockout mouse and use thereof
Inventors:Lowell, Bradford B.; Southborough, MA
Summary:This invention describes a method for providing a transgenic mouse that lacks the UCP2 gene which encodes the UCP2 protein, thereby yielding a mouse that releases an increased level of insulin in response to glucose stimulation. The mouse thus provides a source of cells that are useful in the identification and evaluation of the signaling ability of agents, such as in beta-cells, and which therefore constitutes a method of treating diseases and conditions associated with UCP2 function.
Abstract:The present invention provides a transgenic non-human mammal which lacks a functional UCP2 gene. The UCP-2 deficient transgenic knockout mammal described herein provides a source of cells and animals useful to practice methods for the identification and/or evaluation of agents for their ability to affect signaling in cells, such as pancreatic .beta.-cells, in which ATP serves a regulatory function. Further aspect of the invention provide a method for the identification of agents (e.g., therapeutic agents) which inhibit UCP2 activity; a method for the identification of agents which mimic UCP2 activity and a method of treating diseases or conditions associated with UCP2 function (e.g., negative regulation or uncoupling activity).
US Patent Website:Click Here for Full Text of Patent
Title Number:US6365796
Application Number:US2000000505298
Date Filed:16/02/2000
Date Published:02/04/2002
Assignee:Beth Israel Deaconess Medical Center, Boston, MA, USA


 
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