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| Title: | Composition comprising midkine or pleiotrophin protein and method of increasing hematopoietic cells |
| Inventors: | Kikuchi, Makoto; Fukuoka, Japan Ikematsu, Shinya; Kanagawa, Japan Oda, Munehiro; Kanagawa, Japan Sakuma, Sadatoshi; Kanagawa, Japan Muramatsu, Takashi; Aichi, Japan |
| Summary: | Described herein is a novel promoter for the differentiation and growth of mammalian hematopoietic stem cells and prodromal hematopoietic cells. The invention relates to the novel use of the MK family when used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. Further disclosed is an agent for remarkably enhancing such an effect in promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO. Therapeutic applications are included, such as in the treatment of neutropenia and in the ex vivo expansion of hematopoietic stem cells in bone marrow transplantation. |
| Abstract: | The present invention provides novel use of the MK family that is used alone as an agent for proliferating hematopoietic stem cells and hematopoietic precursor cells. The invention also provides an agent for remarkably enhancing the above-described effect for promoting the proliferation of hematopoietic stem cells and hematopoietic precursor cells, comprising the MK family in combination with known hematopoietic factors such as IL-3, IL-6, G-CSF, GM-CSF, M-CSF, SCF, and EPO. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6383480 |
| Application Number: | US1999000214569 |
| Date Filed: | 07/01/1999 |
| Date Published: | 07/05/2002 |
| Assignee: | Meiji Milk Products, Co., Ltd., Tokyo, Japan |