Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6383481

Title:Method for transplantation of hemopoietic stem cells
Inventors:Ikehara, Susumu; Osaka, Japan
Inaba, Muneo; Kyoto, Japan
Takeuchi, Kenji; Osaka, Japan
Kushida, Taketoshi; Amagasaki, Japan
Summary:Described herein is a novel pharmaceutical composition for hematopoietic stem cell transplantation, composed of hematopoietic stem cells that are irradiated with an effective dose of radiation as an active ingredient. The invention relates to a method of transplanting hemopoietic stem cells via subjecting a recipient to a radiation treatment using an effective exposure dose for hemopoietic stem cell transplantation in advance of administering hemopoietic stem cells from a donor via the portal vein, thereby avoiding the graft failure and rejection rate of donor cells. Specific therapeutic applications in the treatment of autoimmune diseases are included.
Abstract:This invention relates to a method of transplanting hemopoietic stem cells which Comprises subjecting a recipient to a radiation treatment using an effective exposure dose for hemopoietic stem cell transplantation in advance and administering hemopoietic stem cells from a donor from the portal vein. By this method the graft failure/rejection of donor cells can be avoided to thereby maintain the transplant in satisfactory condition.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6383481
Application Number:US1999000265418
Date Filed:10/03/1999
Date Published:07/05/2002
Assignee:Japan Immunoresearch Laboratories Co., Ltd., Gunma-Ken, Japan


 
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