Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6384298

Title:Transgenic mice depleted in a mature lymphocytic cell-type
Inventors:Krimpenfort, Paulus Jacobus Angelinus; Amsterdam, Netherlands Maria Berns, Antonius Jozef; Spaarndam, Netherlands
Summary:cells, and which are produced using a transgene encoding a lymphatic polypeptide variant to inhibit formation. The invention relates to a transgenic mouse having a genome containing a transgene comprising a DNA sequence encoding a T cell receptor (TCR) ? variant in operable linkage with a promoter sequence, wherein the transgene is expressed in at least a precursor cell of a T cell, such that expression of the transgene results in the transgenic mouse exhibiting inhibition of T cell maturation when compared to T cell maturation in a wildtype mouse. The transgene is further described as comprising a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type. Therapeutic immunological applications are included.
Abstract:Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprises a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6384298
Application Number:US1997000899708
Date Filed:24/07/1997
Date Published:07/05/2002
Assignee:Genpharm International, Milpitas, CA, USA


 
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