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Stem Cell Related Patent Number US6384298
| Title: | Transgenic mice depleted in a mature lymphocytic cell-type | | Inventors: | Krimpenfort, Paulus Jacobus Angelinus; Amsterdam, Netherlands
Maria Berns, Antonius Jozef; Spaarndam, Netherlands | | Summary: | cells, and which are produced using a transgene encoding a lymphatic polypeptide variant to inhibit formation. The invention relates to a transgenic mouse having a genome containing a transgene comprising a DNA sequence encoding a T cell receptor (TCR) ? variant in operable linkage with a promoter sequence, wherein the transgene is expressed in at least a precursor cell of a T cell, such that expression of the transgene results in the transgenic mouse exhibiting inhibition of T cell maturation when compared to T cell maturation in a wildtype mouse. The transgene is further described as comprising a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type. Therapeutic immunological applications are included. | | Abstract: | Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprises a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6384298 | | Application Number: | US1997000899708 | | Date Filed: | 24/07/1997 | | Date Published: | 07/05/2002 | | Assignee: | Genpharm International, Milpitas, CA, USA |
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