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Stem Cell Related Patent Number US6387369
| Title: | Cardiac muscle regeneration using mesenchymal stem cells | | Inventors: | Pittenger, Mark F.; Severna Park, MD, USA | | Summary: | Described herein are methods of administrating cardiomyocyte-producing mesenchymal stem cells into the heart. The invention relates to a process for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte-producing amount of mesenchymal stem cells, which may be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. Further disclosed are methods by which the cells can be genetically modified to enhance myocardial differentiation and integration. Also provided is a method for replacing cells ex vivo in a heart valve for implantation. Additional therapeutic applications in the repair of striated cardiac muscle are included. | | Abstract: | Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6387369 | | Application Number: | US2000000446952 | | Date Filed: | 27/03/2000 | | Date Published: | 14/05/2002 | | Assignee: | Osiris Therapeutics, Inc., Baltimore, MD, USA |
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