Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6387369

Title:Cardiac muscle regeneration using mesenchymal stem cells
Inventors:Pittenger, Mark F.; Severna Park, MD, USA
Summary:Described herein are methods of administrating cardiomyocyte-producing mesenchymal stem cells into the heart. The invention relates to a process for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte-producing amount of mesenchymal stem cells, which may be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. Further disclosed are methods by which the cells can be genetically modified to enhance myocardial differentiation and integration. Also provided is a method for replacing cells ex vivo in a heart valve for implantation. Additional therapeutic applications in the repair of striated cardiac muscle are included.
Abstract:Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6387369
Application Number:US2000000446952
Date Filed:27/03/2000
Date Published:14/05/2002
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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