Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6410268

Title:Polynucleotides encoding chemokine alpha-3
Inventors:Ni, Jian; Rockville, MD, USA
Li, Haodong; Gaithersburg, MD, USA
Su, Jeffrey; Gaithersburg, MD, USA
Summary:Described herein are novel human chemokine alpha-3 polypeptides, the DNA (RNA) encoding such chemotactic cytokines, and a procedure for producing such polypeptides by recombinant techniques. Further disclosed are antagonists against such chemotactic cytokines and their therapeutic application in the treatment of rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure. Also provided are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides, as well as diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host. Additional therapeutic applications are included, such as in the treatment of various diseases such as leukemia and auto immune disorders.
Abstract:Human chemokine Alpha-3 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, sepsis, wound healing and psoriasis and to stimulate stem cell mobilization. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, ARDS and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6410268
Application Number:US1997000816772
Date Filed:18/03/1997
Date Published:25/06/2002
Assignee:Human Genome Sciences, Inc., Rockville, MD, USA


 
Copyright © 2007 The Institute for Cellular Medicine  6/18/2021