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Stem Cell Related Patent Number US6410825
| Title: | A-myb null mutant transgenic mice | | Inventors: | Toscani, Antonio; late of Philadelphia, PA, USA
Toscani, Donato; Teramo, Italy
Hatton, Kimi; Fairfax, VA, USA
Reddy, E. Premkumar; Villanova, PA, USA | | Summary: | This invention introduces a novel transgenic non-human mammal with a homozygous functionally disrupted A-myb locus in the genome. Described herein are targeting constructs used to produce such transgenic stem cells and the resulting transgenic mouse, such that the transgenic mouse is an infertile male. Further disclosed are methods for inactivating an endogenous A-myb gene locus, as well as methods for generating transgenic sperm and transgenic nonhuman animals harboring a desired transgene. Applications as a model for male infertility and for the study of spermatogenesis are included. | | Abstract: | Transgenic non-human animals and transgenic non-human stem cells are described having a functionally disrupted A-myb locus. Targeting constructs used to produce such transgenic stem cells and animals, and methods and targeting constructs for inactivating an endogenous A-myb gene locus, are also provided. Also provided are methods for generating transgenic sperm and transgenic nonhuman animals harboring a desired transgene. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6410825 | | Application Number: | US2000000402929 | | Date Filed: | 22/03/2000 | | Date Published: | 25/06/2002 | | Assignee: | Temple University-Of The Commonwealth System of Higher Education, Philadelphia, PA, USA |
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