Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6419917

Title:Human chemotactic protein
Inventors:Li, Haodong; Gaithersburg, MD, USA
Ruben, Steven M.; Olney, MD, USA
Sutton, III, Granger; Columbia, MD, USA
Summary:This invention introduces methods of inducing the local accumulation of eosinophils via the administration of a human chemotactic polypeptide. Disclosed herein is a human chemotactic polypeptide, the DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques. Therapeutic applications include stem cell mobilization, myeloprotection, neuronal protection, the treatment of tumors, the treatment of parasitic infection, the regulation of hematopoiesis, and the promotion of wound healing. Also provided are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequences encoding a polypeptide which may be used for detecting altered levels of the polypeptide in the detection of disease.
Abstract:A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6419917
Application Number:US1999000453416
Date Filed:03/12/1999
Date Published:16/07/2002
Assignee:Human Genome Sciences, Inc., Rockville, MD, USA


 
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