Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6432917

Title:Inhibitor of stem cell proliferation and uses thereof
Inventors:Kozlov, Vladimir; Novosibirsk, Russian Federation Tsyrlova, Irena; Gaithersburg, MD, USA
Summary:This invention introduces novel methods and compositions for inhibiting stem cell proliferation. Described herein is a process of contacting hemoglobin chains with a stem cell proliferation inhibiting amount of a composition comprised of a component isolated from bone marrow. Further disclosed are methods of extraction and filtration for obtaining such bone marrow components. Claims of the invention include stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating post-chemotherapy peripheral blood cell recovery. Therapeutic applications are included, such as in the protection of stem cells from antiviral agents, in the treatment of cancer, and in the maintenance of mammalian hematopoietic stem cells ex vivo.
Abstract:Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6432917
Application Number:US1995000477669
Date Filed:07/06/1995
Date Published:13/08/2002
Assignee:Pro-Neuron, Inc., Gaithersburg, MD, USA


 
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