Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6440141

Title:Method and apparatus for treating osteochondral pathologies
Inventors:Philippon, Marc J.; Boca Raton, FL, USA
Summary:Described herein are surgical instruments for treating osteochondral pathologies such as chondromalacia. The instruments are described as comprising an advancement mechanism for transferring an implantable prosthesis from the magazine to the trocar lumen when the drill located in the trocar lumen is retracted. The invention relates to an implantable prosthesis which includes a porous substrate and a substance positioned within the porous substrate. The substance is described as being elutable such that a baited route is provided to attract mesenchymal stem cells from the cancellous bone underlying the articular surfaces up to chondral lesions within the joint, thereby promoting the growth of chondrocytes in the area of the chondral lesions.
Abstract:Systems and methods are described for treating osteochondral pathologies. An implantable prosthesis for treating osteochondral pathologies includes: a porous substrate; and a substance positioned within the porous substrate that is elutable with regard to the porous substrate. The systems and methods provide advantages because a baited route is provided to attract mesenchymal stem cells from the cancellous bone underlying the articular surfaces up to chondral lesions within the joint, thereby promoting the growth of chondrocytes in the area of the chondral lesions.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6440141
Application Number:US2000000624689
Date Filed:24/07/2000
Date Published:27/08/2002
Assignee:Oratec Interventions, Inc., Menlo Park, CA, USA


 
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