Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6447766

Title:Method of mobilizing hematopoietic stem cells
Inventors:Pelus, Louis Martin; Richboro, PA, USA
King, Andrew Garrison; Blue Bell, PA, USA
Qian, Yanqiu; King of Prussia, PA, USA
Summary:Described herein are modified chemokines and their use in the mobilization of hematopoietic stem cells. The invention relates to methods of mobilizing hematopoietic stem cells from the bone marrow to the peripheral circulation via the administration to a mammalian subject of an effective amount of mature, modified or multimeric forms of KC, grobeta, groalpha, or grogamma. The modified chemokines are described as consisting of amino acids 5 to 73 of SEQ ID NO: 3 wherein the amino acid number 69 has been deamidated to aspartic acid or isoaspartic acid. Further disclosed is a multimeric chemokine comprising an aggregation of two or more desamino gro-? proteins. Therapeutic applications in cell transplants are included.
Abstract:A method of mobilizing hematopoietic stem cells from the bone marrow to the peripheral circulation is provided by administering to an animal an effective amount of mature, modified or multimeric forms of KC, gro.beta., gro.alpha., or gro.gamma..
US Patent Website:Click Here for Full Text of Patent
Title Number:US6447766
Application Number:US1999000467155
Date Filed:20/12/1999
Date Published:10/09/2002
Assignee:SmithKline Beecham Corporation, Philadelphia, PA, USA


 
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