Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6451562

Title:Polypeptides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) polynucleotides
Inventors:Ruben, Steven M.; Olney, MD, USA
Li, Haodong; Gaithersburg, MD, USA
Summary:Described herein are novel purifying target proteins from inclusion bodies, methods and uses thereof. The invention relates to an isolated nucleic acid molecule composed of at least 30 contiguous nucleotides, and methods by which such molecules are treating with low concentrations of a chaotropic agent for solubilizing the protein for recovery. Further disclosed are therapeutic compositions and methods using the isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine ?8(CK?8 or ckb-8)), a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-? and chemokine ?1 (CK?1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves. Also provided are vectors, host cells and recombinant methods for their production.
Abstract:There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine .beta.8(CK.beta.8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-.gamma. and chemokine .beta.1 (CK.beta.1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6451562
Application Number:US1999000334951
Date Filed:17/06/1996
Date Published:17/09/2002
Assignee:Human Genome Sciences, Inc., Rockville, MD, USA


 
Copyright © 2007 The Institute for Cellular Medicine  6/18/2021