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Stem Cell Related Patent Number US6452065
| Title: | Transgenic mouse expressing non-native wild-type and familial Alzheimer's Disease mutant presenilin 1 protein on native presenilin 1 null background | | Inventors: | Zheng, Hui; Edison, NJ, USA | | Summary: | This invention introduces a new transgenic nonhuman mammal expressing a non-native presenilin-1 mutant or allele. Described is a transgenic mouse embryo lacking native presenilin 1 and also a transgenic mouse embryo having only a non-native presenilin 1. Further disclosed are methods by which the transgenic animals and cells derived therefrom can be used in the study of the expression pattern, activity and modulators of presenilin 1, and in the study of the role of presenilin 1 in disorders of the central nervous system. The authors introduce a transgenic mouse embryo whose genome is homozygous for a disruption of a native presenilin-1 gene, such that production of functional presenilin-1 is inhibited, and the embryo exhibits abnormal axial skeleton development. Applications are also provided by which such a model may be useful in the study of the etiology of Familial Alzheimer's Disease (FAD). | | Abstract: | The present invention relates to a transgenic non-human animal embryo lacking native presenilin 1 and a transgenic non-human animal having only a non-native presenilin 1. The transgenic animals and cells derived therefrom can be used in the study of the expression pattern, activity and modulators of presenilin 1, in the study of the role of presenilin 1 in Alzheimer's Disease and in the study of disorders of the central nervous system. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6452065 | | Application Number: | US1998000078871 | | Date Filed: | 14/05/1998 | | Date Published: | 17/09/2002 | | Assignee: | Merck and Co., Inc., Rahway, NJ, USA
Johns Hopkins University, Baltimore, NJ, USA |
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