Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6461645

Title:Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
Inventors:Boyse, Edward A.; Tucson, AZ, USA
Broxmeyer, Hal E.; Indianapolis, IN, USA
Douglas, Gordon W.; Mendham, NJ, USA
Summary:This invention introduces a novel cryopreserved pharmaceutical composition comprised of viable human neonatal or fetal hematopoietic stem cells from umbilical cord blood or placental blood, including a cryopreservative and carrier. Therapeutic applications of such cryopreserved cells upon thawing are directed toward hematopoietic/immune reconstitution in the treatment or prevention of various diseases and disorders such as anemias, malignancies, autoimmune disorders, and various immune dysfunctions and deficiencies. Further described are the means by which such fetal or neonatal hematopoietic stem and progenitor cells which contain a heterologous gene sequence may be used for hematopoietic reconstitution in gene therapy as well as for autologous reconstitution. Multiple embodiments of the invention are provided.
Abstract:The present invention relates to hematopoietic stem and progenitor cells of neonatal or fetal blood that are cryopreserved, and the therapeutic uses of such stem and progenitor cells upon thawing. In particular, the present invention relates to the therapeutic use of fetal or neonatal stem cells for hematopoietic (or immune) reconstitution. Hematopoietic reconstitution with the cells of the invention can be valuable in the treatment or prevention of various diseases and disorders such as anemias, malignancies, autoimmune disorders, and various immune dysfunctions and deficiencies. In another embodiment, fetal or neonatal hematopoietic stem and progenitor cells which contain a heterologous gene sequence can be used for hematopoietic reconstitution in gene therapy. In a preferred embodiment of the invention, neonatal or fetal blood cells that have been cryopreserved and thawed can be used for autologous (self) reconstitution.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6461645
Application Number:US1990000525428
Date Filed:16/05/1990
Date Published:08/10/2002
Assignee:PharmaStem Therapeutics, Inc., Del Mar, CA, USA


 
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