Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6464983

Title:Methods and uses of connective tissue growth factor for differentiation of mesenchymal stem cells
Inventors:Grotendorst, Gary R.; Miami, FL, USA
Summary:Described herein are methods of inducing differentiation of mesenchymal stem cells, by contacting the cells ex vivo with a connective tissue growth factor in order to induce differentiation of the stem cells into chondrocytes or osteoblasts. The invention relates to novel methods and compositions for the administration of a connective tissue growth factor, alone or in combination with other growth factors, compositions or compounds, such that the mesenchymal stem cells are contacted ex vivo with an effective amount of Connective Tissue Growth Factor (CTGF), so as to induce differentiation of the mesenchymal stem cells into a specific cell type selected from the group consisting of chondrocytes and osteoblasts.
Abstract:The present invention relates to novel methods and compositions related to the administration of connective tissue growth factor, alone or in combination with other growth factors, compositions or compounds, to induce the differentiation of mesenchymal stem cells into chondrocytes or asteablasts.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6464983
Application Number:US1998000122135
Date Filed:24/07/1998
Date Published:15/10/2002
Assignee:University of South Florida, Tampa, FL, USA University of Miami, Miami, FL, USA


 
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