Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6475988

Title:Methods to increase white blood cell survival after chemotherapy
Inventors:Rodgers, Kathleen E.; Long Beach, CA, USA
DiZerega, Gere; Pasadena, CA, USA
Summary:This invention describes novel angiotensinogen or angiotensin peptides, and their ability to increase white blood cell survival. Therapeutic applications are specifically directed to the treatment of cancer patients following chemotherapy. Further disclosed are methods, kits, and pharmaceutical compositions for increasing the white blood cell survival in such patients, as well as methods by which hematopoietic progenitor cells may be mobilized from bone marrow into the peripheral blood. Also provided are means for the administration of an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists, in the mobilization of such hematopoietic progenitor cells in such patients.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US6475988
Application Number:US1999000307940
Date Filed:10/05/1999
Date Published:05/11/2002
Assignee:University of Southern California, Los Angeles, CA, USA


 
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