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| Title: | Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative |
| Inventors: | Abatangelo, Giovanni; 35030 Saccolongo (Prov. of Padova), Italy Callegaro, Lanfranco; 35016 Thiene (Prov. of Vicenza), Italy Young, Randell G.; Ellicott City, MD, USA Murphy, Josephine Mary; Baltimore, MD, USA Fink, David Jordan; Baltimore, MD, USA Bruder, Scott Philip; Owings Mills, MD, USA Barry, Francis Peter; Baltimore, MD, USA Kadiyala, Sudhakar; Baltimore, MD, USA Caplan, Arnold I.; Cleveland Heights, OH, USA Moskowitz, Roland; Shaker Heights, OH, USA Yoo, Jung U.; Shaker Heights, OH, USA Solchaga, Luis A.; University Heights, OH, USA |
| Summary: | Described herein is a novel biological material, and its uses in the repair of connective tissue. The invention relates to a material comprised of an extracellular matrix from specific connective tissue cells, and a three-dimensional matrix of a hyaluronic acid derivative. Methods of preparation are provided, as are uses of the material as a substrate for the in vitro growth of keratinocytes. Therapeutic applications include the treatment of injuries to cartilage, bone and skin. |
| Abstract: | A biological material for the repair of connective tissue cells comprising: a) a cell preparation enriched in mesenchymal stem cells, b) three-dimensional extracellular matrix comprising a nyaluronic acid derivative. The use of said biological material, optionally combined with therapeutically acceptable excipients and/or diluents and optionally in association with therapeutically effective ingredients in the repair of connective tissue cells. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6482231 |
| Application Number: | US2000000602033 |
| Date Filed: | 23/06/2000 |
| Date Published: | 19/11/2002 |
| Assignee: | None |