Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6482231

Title:Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative
Inventors:Abatangelo, Giovanni; 35030 Saccolongo (Prov. of Padova), Italy
Callegaro, Lanfranco; 35016 Thiene (Prov. of Vicenza), Italy
Young, Randell G.; Ellicott City, MD, USA
Murphy, Josephine Mary; Baltimore, MD, USA
Fink, David Jordan; Baltimore, MD, USA
Bruder, Scott Philip; Owings Mills, MD, USA
Barry, Francis Peter; Baltimore, MD, USA
Kadiyala, Sudhakar; Baltimore, MD, USA
Caplan, Arnold I.; Cleveland Heights, OH, USA
Moskowitz, Roland; Shaker Heights, OH, USA
Yoo, Jung U.; Shaker Heights, OH, USA
Solchaga, Luis A.; University Heights, OH, USA
Summary:Described herein is a novel biological material, and its uses in the repair of connective tissue. The invention relates to a material comprised of an extracellular matrix from specific connective tissue cells, and a three-dimensional matrix of a hyaluronic acid derivative. Methods of preparation are provided, as are uses of the material as a substrate for the in vitro growth of keratinocytes. Therapeutic applications include the treatment of injuries to cartilage, bone and skin.
Abstract:A biological material for the repair of connective tissue cells comprising: a) a cell preparation enriched in mesenchymal stem cells, b) three-dimensional extracellular matrix comprising a nyaluronic acid derivative. The use of said biological material, optionally combined with therapeutically acceptable excipients and/or diluents and optionally in association with therapeutically effective ingredients in the repair of connective tissue cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6482231
Application Number:US2000000602033
Date Filed:23/06/2000
Date Published:19/11/2002
Assignee:None


 
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