Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6482598

Title:Antibody recognizing a small subset of human hematopoietic cells
Inventors:Lawman, Michael J. P.; Key Largo, FL, USA
Lawman, Patricia; Key Largo, FL, USA
Summary:This invention describes a novel antibody specific for an antigen on a subset of primitive hematopoietic cells, as well as methods of contacting and recovering such hematopoeitic cells. Described herein are antibodies that have binding specificity for an antigen that is expressed on a subset of human hematopoietic mononuclear cells, including a hematopoietic stem cell population, but which is not expressed on normal, mature myeloid cells. Further disclosed are cell suspensions containing a monoclonal antibody, MG1+, which is described as being useful in methods of isolating cell suspensions from human blood and marrow. Therapeutic applications are included, such as in the diagnosis and treatment of leukemia, for bone marrow reconstitution and other diseases of the hematopoetic system, and in gene therapy.
Abstract:The subject invention pertains to antibodies that have binding specificity for an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal, mature myeloid cells. In one embodiment, a monoclonal antibody, MG1, is provided. This antibody is useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation, genetic therapy, and in treating other diseases of the hematopoietic system. Cell suspensions containing MG1.sup.+ human hematopoietic cells are also provided, as well as therapeutic methods employing the cell suspensions. The subject invention also pertains to the novel antigen recognized by the subject antibodies.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6482598
Application Number:US2001000873835
Date Filed:04/06/2001
Date Published:19/11/2002
Assignee:Morphogenesis, Inc., Chipley, FL, USA


 
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