Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6485722

Title:Method for selective engraftment of drug-resistant hematopoietic stem cells
Inventors:McIvor, R. Scott; St. Louis Park, MN, USA
James, Rohaizah I.; Fridley, MN, USA
May, Chad; New York, NY, USA
Summary:Described herein are methods for increasing the efficiency of hematopoietic cell engraftment in vivo by the administration of transgenic stem cells with DNA encoding resistance to a normally toxic agent. The invention relates to transgenic hematopoietic stem cells which are described as having a selective advantage over nontransgenic hematopoietic cells, and methods by which the efficacy of engraftment of such hematopoietic stem cells is increased. Therapeutic applications in protecting patients from the toxic effects of chemotherapy are included.
Abstract:A method to increase the efficiency of hematopoietic stem cell engraftment in vivo is provided.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6485722
Application Number:US1999000142126
Date Filed:06/07/1999
Date Published:26/11/2002
Assignee:Regents of the University of Minnesota, Minneapolis, MN, USA


 
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