Methods comprising apoptosis inhibitors for the generation of transgenic pigs |
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| Title: | TRANSGENIC MAMMALS LACKING EXPRESSION OF ERYTHROPOIETIN OR OF ERYTHROPOIETIN RECEPTOR, TRANSGENIC MAMMALS EXPRESSING CHIMERIC ERYTHROPOIETIN RECEPTORS, CONSTRUCTS FOR PRODUCING THE TRANSGENIC MAMMALS AND USES THEREFOR |
| Inventors: | Wu, Hong; Brookline, MA, USA Liu, Xin; Brookline, MA, USA Lodish, Harvey F.; Brookline, MA, USA Giebel, Lutz B.; San Mateo, CA, USA Ross, Michael J.; Hillsborough, CA, USA Matthews, David; San Francisco, CA, USA |
| Summary: | This invention introduces novel DNA constructs having specific fragments of erythropoietin (Epo) or an Epo receptor gene and selectable marker, and the resulting transgenic nonhuman mammals. Described herein are transgenic mice lacking erythropoietin expression, in which the erythropoietin receptor is deleted, and which carry a heterologous erythropoietin receptor such as a chimeric receptor. Further disclosed are the methods by which such transgenic mice are produced, along with methods for the production of embryonic stem cells containing such constructs, and methods for identifying erythropoietin mimics or mimetics. |
| Abstract: | Transgenic nonhuman mammals, such as transgenic mice, which lack erythropoietin expression, in which the erythropoietin receptor is deleted, which carry a heterologous erythropoietin receptor (e.g., a chimeric receptor); constructs useful for producing such transgenic nonhuman mammals, embryonic stem cells containing the constructs, a method of producing the transgenic nonhuman mammals and a method of identifying erythropoietin mimics or mimetics. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6485964 |
| Application Number: | US1997000839605 |
| Date Filed: | 15/04/1997 |
| Date Published: | 26/11/2002 |
| Assignee: | Arris Pharmaceutical Corporation, South San Francisco, CA, USA Whitehead Institute for Biomedical Research, Cambridge, MA, USA |