Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6492493

Title:Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
Inventors:Celeste, Anthony J.; Hudson, MA, USA
Murray, Beth L.; Arlington, MA, USA
Summary:This invention introduces the novel purified bone morphogenic protein-17 and -18 (BMP-17 and BMP-18) polypeptides, methods and uses thereof. Further disclosed are DNA molecules encoding the BMP-17 and BMP-18 proteins. Claims of the invention include therapeutic applications of such proteins in the treatment of bone, cartilage, and other connective tissue defects and disorders, and in the regeneration of other tissues and organs including hepatic, respiratory, epithelium, neurological, spleen, cardiac, pancreatic and renal tissue. Specific amino acid sequences are provided, as are methods by which the BMP-17 and BMP-18 proteins may also be used for the induction of growth and differentiation of undifferentiated embryonic stem cells.
Abstract:Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6492493
Application Number:US1999000438623
Date Filed:12/11/1999
Date Published:10/12/2002
Assignee:Genetics Institute, LLC, Cambridge, MA, USA


 
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