Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6492575

Title:Method for developing transgenic mice
Inventors:Wagner, Erwin; Vienna, Austria Wang, Zhao-Qi; Lyon, France
Summary:This invention introduces a novel method for producing a nonhuman transgenic mammal. The invention relates to a process of inserting totipotent embryonic stem cells or embryonic germ cells into tetraploid blastocysts which are transferred to surrogate mothers for purposes of producing a transgenic mouse with a desired genotype. Further disclosed are the means by which the embryonic stem cells or embryonic germ cells have been genetically manipulated in order to produce the resultant desired genetic characteristics. Methods, applications, and uses thereof are provided.
Abstract:Process for producing mammals with defined genetic properties, particularly transgenic mammals. Animals which are derived completely from ES cells are obtained by injecting totipotent cells (embryonic stem cells or embryonic germ cells) genetically manipulated and cultured in vitro into tetraploid blastocysts and implanting the resulting embryo in a foster mother, in a single operation.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6492575
Application Number:US1999000242406
Date Filed:28/12/1999
Date Published:10/12/2002
Assignee:Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany


 
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