Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6495129

Title:Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3)
Inventors:Li, Haodong; Gaithersburg, MD, USA
Ruben, Steven M.; Olney, MD, USA
Summary:Described herein are methods of treating or preventing cytotoxic agent-induced damage to cells, via the administration of a myeloid progenitor inhibitor factor-1 polypeptide. The invention relates to therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine ?8 (CK?8 or ckb-8)), as well as the MPIF-1 polypeptide itself. Further disclosed are vectors, host cells and recombinant methods for their production.
Abstract:There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine .beta.8 (CK.beta.8 or ckb-8)), as well as MPIF-1 polypeptide itself, as are vectors, host cells and recombinant methods for producing the same.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6495129
Application Number:US2000000689693
Date Filed:13/10/2000
Date Published:17/12/2002
Assignee:Human Genome Sciences, Inc., Rockville, MD, USA


 
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