Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6495365

Title:Hematopoietic stem cell proliferating agents
Inventors:Saito, Yoshimasa; Kawanishi, Japan
Ueda, Yoshiko; Osaka, Japan
Tamura, Kouichi; Kobe, Japan
Takata, Yoko; Osaka, Japan
Yamada, Hisashi; Sanda, Japan
Yamashita, Tatsuo; Kobe, Japan
Kobayashi, Masakazu; Takarazuka, Japan
Summary:Described herein is a hematopoietic stem cell proliferation agent containing IGF-I as well as at least one protein selected from among SCF, M-CSF, and G-CSF. The invention relates to methods by which the selected hematopoietic stem cell proliferating agent causes hematopoietic stem cells to proliferate in the undifferentiated state whether in vivo or in vitro. Therapeutic applications are included, such as in the use of this type of agent for the amelioration of cytopenia induced by radiotherapeutic or chemotherapeutic anti-cancer drugs. Further therapeutic applications are provided for the prevention of infectious diseases associated with lymphopenia, or in vitro culture for multiplication of hematopoietic stem cells and for the extrasomatic culture of recombinant stem cells in gene therapy.
Abstract:This invention relates to a hematopoietic stem cell proliferating agent comprising IGF-I, a hematopoietic stem cell proliferating agent comprising IGF-I and at least one protein selected from among SCF, M-CSF, and G-CSF, and a method of growing hematopoietic stem cells which comprises culturing hematopoietic stem cells in a medium containing IGF-I and at least one protein selected from the group consisting of SCF and M-CSF. The hematopoietic stem cell proliferating agent of the invention causes hematopoietic stem cells to proliferate in the undifferentiated state whether in vivo or in vitro and can, therefore, be used for amelioration of the cytopenia induced by radiotherapy or chemotherapy using anticancer drugs, prevention of infectious diseases associated with lymphopenia, or in vitro culture for multiplication of hematopoietic stem cells and extrasomatic culture of recombinant stem cells in gene therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6495365
Application Number:US1999000147689
Date Filed:13/05/1999
Date Published:17/12/2002
Assignee:Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan


 
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