Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6497872

Title:Neural transplantation using proliferated multipotent neural stem cells and their progeny
Inventors:Weiss, Samuel; Alberta, Canada
Reynolds, Brent; Alberta, Canada
Hammang, Joseph P.; Barrington, RI, USA
Baetge, E. Edward; Barrington, RI, USA
Summary:This invention describes methods of transplanting multipotent neural stem cell progeny to a host via obtaining a population of cells derived from mammalian neural tissue containing multipotent central nervous system (CNS) neural stem cells. The invention relates to CNS neural stem cells which are proliferated in a culture medium supplemented with one or more mitrogens, such that the CNS neural stem cells also retain the capacity for renewed proliferation and for multipotency. Further disclosed are the means by which such cells are selectively differentiated into neurons, astrocytes, and oligodendrocytes and transplanted into a host.
Abstract:The invention provides methods of transplanting multipotent neural stem cell progeny to a host by obtaining a population of cells derived from mammalian neural tissue containing at least one multipotent CNS multipotent neural stem cell; culturing the neural stem cell in a culture medium containing one or more growth factors which induce multipotent neural stem cell proliferation; inducing proliferation of the multipotent neural stem cell to produce neural stem cell progeny which includes multipotent neural stem cell progeny cells; and transplanting the multipotent neural stem cell progeny to the host. Also provided are methods of transplanting neural stem cell progeny to a host by obtaining an in vitro cell culture containing CNS neural stem cells where one or more cells in the culture (i) proliferates in a culture medium supplemented with one or more mitrogens, (ii) retains the capacity for renewed proliferation, and (iii) maintains the multipotential capacity, under suitable culture conditions, to differentiate into neurons, astrocytes, and oligodendrocytes; and transplanting the one or more cells to the hose.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6497872
Application Number:US1995000486313
Date Filed:07/06/1995
Date Published:24/12/2002
Assignee:NeuroSpheres Holdings Ltd., Calgary, Canada


 
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