Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6498018

Title:Cultures of human CNS neural stem cells
Inventors:Carpenter, Melissa; Foster City, CA, USA
Summary:Described herein are novel neural stem cell cultures, methods and uses thereof. The invention relates to a method for determining the effect of a biological agent via contacting a cell culture with the biological agent. The cell culture is described as containing one or more preselected growth factors effective for inducing multipotent central nervous system (CNS) neural stem cell proliferation, as well as human multipotent CNS neural stem cells that are derived from primary CNS neural tissue and which have a doubling rate faster than 30 days and which are suspended in the culture medium. Therapeutic applications are included, such as in the treatment of epilepsy, stroke, Huntington's disease, Alzheimer's disease, multiple sclerosis, and neuropathies.
Abstract:The invention provides a method for determining the effect of a biological agent comprising contacting a cell culture with a biological agent. The cell culture of the invention contains a culture medium containing one or more preselected growth factors effective for inducing multipotent central nervous system (CNS) neural stem cell proliferation. The cell culture also contains, suspended in the culture medium, human multipotent CNS neural stem cells that are derived from primary CNS neural tissue that have a doubling rate faster than 30 days.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6498018
Application Number:US2000000486302
Date Filed:16/10/2000
Date Published:24/12/2002
Assignee:Cytotherapeutics, Inc., Lincoln, RI, USA


 
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