Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6500943

Title:Promoter
Inventors:Mano, Hiroyuki; Utsunomiya, Japan
Sakata, Tsuneaki; Toyonaka, Japan
Hasegawa, Mamoru; Tsukuba, Japan
Tabata, Toshiaki; Tsukuba, Japan
Summary:This invention introduces DNA with a Tec tyrosine kinase promoter activity for the expression of foreign genes in hematopoietic stem cells and liver cells. Described herein are methods of providing a DNA with promoter activity of Tec tyrosine kinase and a vector having incorporated within it the promoter which thereby enables a high level expression of an exogenous gene in hematopoietic stem cells and hepatic cells. Precise nucleotide sequences are disclosed, as are therapeutic applications in the treatment of liver disease.
Abstract:The present invention provides a DNA having promoter activity of Tec tyrosine kinase and a vector having incorporated within it the promoter to thereby enable a high level expression of an exogenous gene in hematopoietic stem cells and hepatic cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6500943
Application Number:US2001000045428
Date Filed:08/11/2001
Date Published:31/12/2002
Assignee:Dnavec Research Inc., Ibaraki, Japan


 
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