Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6514513

Title:Costimulatory blockade and mixed chimerism in transplantation
Inventors:Sykes, Megan; Charlestown, MA, USA
Summary:Described herein are methods of promoting the acceptance of a xenograft within a recipient. The invention relates to a method of promoting acceptance, by a recipient mammal, of a graft from a donor mammal of a second species. Further disclosed are processes by which a recipient is administered an inhibitor of a costimulatory pathway. Also provided are methods of introducing into the recipient mammal hematopoietic stem cells, as well as methods of implantation of the graft in the recipient.
Abstract:Use of blockade of costimulation and hematopoietic stem cell transplantation in the promotion of graft acceptance.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6514513
Application Number:US1999000244447
Date Filed:04/02/1999
Date Published:04/02/2003
Assignee:The General Hospital Corporation, Boston, MA, USA


 
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