Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6517872

Title:FGFR3 as a marker for mesenchymal skeletal progenitor cells
Inventors:Yayon, Avner; Moshav Sitria, Israel Nevo, Zvi; Herzlia, Israel
Summary:Described herein are methods of identification of mesenchymal skeletal progenitor cells via the use of an agent that binds to the fibroblast growth factor receptor 3 (FGFR3), identified herein as a novel marker for mesenchymal skeletal progenitor cells. The invention relates to a process of utilizing this novel marker in order to identify and locate mesenchymal skeletal progenitor cells in a tissue, as well as to obtain a substantially pure culture of such cells. Applications include use of the mesenchymal skeletal progenitor cells in a pure culture, and optionally after various manipulations ex vivo, as an active ingredient in pharmaceutical compositions or implants for the purpose of bone and cartilage repair. Further therapeutic applications are included by which FGFR3 may be used as a marker for the identification and the localization of cartilage- and bone-derived tumors. Also provided are agents capable of binding to FGFR3 which may be used for the targeting of cytotoxic agents to cartilage- and bone-derived tumors.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US6517872
Application Number:US1998000981031
Date Filed:12/06/1998
Date Published:11/02/2003
Assignee:Yeda Research and Development Co., Ltd., Rehovot, Israel Ramdt University Authority for Applied Research and Industrial Development Ltd., Tel Aviv, Israel


 
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