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Stem Cell Related Patent Number US6534052

Title:Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
Inventors:Xiao, Yong-Fu; Wayland, MA, USA
Morgan, James P.; Newton Centre, MA, USA
Summary:This invention introduces methods for improving cardiac function in a living mammalian subject involves the introduction and implantation of mammalian embryonic stem cells into the infarcted area of myocardium. Described herein is a method for repairing heart tissue in a living mammalian subject after the occurrence of a myocardial infarction, involving a surgical technique which introduces and implants mammalian embryonic stem cells into the infarcted area of the myocardium, after which stable grafts are formed which survive indefinitely within the infarcted area of the heart in the living host. Claims of the invention include demonstrated beneficial effects such as decreased infarcted tissue area and improved cardiac function as assessed by hemodynamic and echocardiographic measurements.
Abstract:The present invention is a method for markedly improving cardiac function and repairing heart tissue in a living mammalian subject after the occurrence of a myocardial infarction. The method is a surgical technique which introduces and implants mammalian embryonic stem cells into the infarcted area of the myocardium. After implantation, the embryonic stem cells form stable grafts and survive indefinitely within the infarcted area of the heart in the living host. The demonstrated beneficial effects of the method include a decreased infarcted area and improved cardiac function as assessed by hemodynamic and echocardiographic measurements.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6534052
Application Number:US2000000655124
Date Filed:05/09/2000
Date Published:18/02/2003
Assignee:None


 
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